Chemical API processing
Process efficiency is key to successful production of chemical active pharmaceutical ingredients (APIs) from complex chemical substances. Increasingly, drug companies look to Alfa Laval as a turnkey supplier of process expertise, hygienic equipment and services for the manufacture of high quality chemical APIs used in finished pharmaceutical products. Equipment from Alfa Laval meets regulatory requirements, supports product stability, lowers manufacturing costs and increases production yields.
Advanced and Compact Hygienic condensers for your API needs.
The pharmaceutical industry has a high hygienic requirement for modern API production. This industry needs a combination of hygienic design, high-performance standards, low operating costs, and easy installation for its plant machinery to ensure patient safety, reliable uptime, and production efficiency. By using Alfa Laval’s advanced and innovative condenser solution in your API plant, you can achieve an efficiency of Condensation of more than 98% in the Primary Condenser itself thus having a possibility to avoid secondary condensers, leading to CAPEX as well as OPEX savings.
Spiral Heat Exchanger
Alfa Laval spiral heat exchangers are designed to handle the toughest heat transfer challenges. They are specifically designed for the pharmaceutical industry and the high hygienic requirements of modern API production The robust, efficient and compact designs keeps both installation and maintenance costs extremely low, and they have a proven reputation for almost never fouling up. Alfa Laval has supplied several thousand SHES to India as well as overseas API Industries. This is supplied for SS Reactors
We have supplied several thousand SHES to Indian as well as overseas API Industries. This we supply for SS Reactors.
- Generally, Heat Transfer Area required is ½, compared to Shell and Tube. K values are between 700 to 1400.
- 100 % Drain ability on the vapour side.
- More than 98% Solvent recovery in primary condenser itself, due to close temperature approach possible
- Venting of non-condensable is effective
- All contact parts of vapours side as well as coolant side in SS 316 L
- Compact in size – required less area as well less installation cost. Easy to install.
- Totally gasket free. So, no Maintenance cost
- Vapour side is 100% visually inspectable.
- CIP able, Backflush cleanable.
Two Pass Compabloc new
Alfa Laval’s Two Pass Compabloc is a compact condenser with very high heat transfer efficiency specifically designed for the pharmaceutical industry and the high hygienic requirements of modern API production.
- This is supplied for Glass line Reactors and Hastelloy Reactors.
- The Heat Transfer Area required ¼ th compared to Shell and Tube. K values between 1500 to 2200.
- 100 % Drain ability
- More than 98% Solvent recovery in Primary condenser itself due to close temperature approach possible
- Venting of non-condensable is effective
- All contact parts of vapours side as well as coolant side in Hastelloy or Exotic MOC
- Compact in size – Required less area as well as less installation cost
- Totally gasket free. So, no Maintenance cost
- Both sides are possible to clean mechanically in case required
- Very low head space is required as it is very compact compared to any other technology
Production of chemical active pharmaceutical ingredients
Manufacturing chemical active pharmaceutical ingredients (APIs) poses distinct challenges because APIs sometimes require a unique set of processes to obtain the final product. Successful processing therefore requires process efficiency to produce stable APIs in a safe, consistent and cost-effective manner while preserving the safety, identity, strength, quality and purity of the drug.
As a knowledgeable partner to pharmaceutical manufacturers, Alfa Laval has a broad range of hygienic equipment. Whether measuring, pumping, separating, diverting, heating, cooling, agitating or mixing, automating, controlling and cleaning for critical processes, Alfa Laval has most everything required to support the production of chemical APIs. Through process optimization, we help you lower costs and cycle times, minimize contamination risks and safeguard the purity and maximize yield of produced APIs.
All components are supplied with comprehensive pharmaceutical documentation packages based on Good Documentation Practice (GDP). For Alfa Laval UltraPure pumps, valves, tank equipment and heat exchangers we have the Alfa Laval Q-doc package which ensures full traceability of all process contact parts of the equipment supplied.
Why choose Alfa Laval?
- Comply with all relevant standards and cGMP
- Provide in-batch and batch-to-batch consistency
- Safeguard product characteristics and quality
- Protect the integrity of the finished product
- Increase uptime and production yields
- Combine maximum hygiene with maximum efficiency
- Reduce energy and water consumption
- Ease commissioning, qualification, cleaning and service
360° Service Portfolio
Alfa Laval hygienic equipment is backed by the Alfa Laval 360° Service Portfolio to extend performance.